MOTS-c
MOTS-C – Mitochondrial-Derived Peptide
Overview
MOTS-C is a 16-amino-acid peptide encoded by mitochondrial DNA and recognized for its role in regulating cellular metabolism. Produced within the mitochondria, this peptide acts as a key messenger that helps maintain energy homeostasis by influencing glucose utilization, insulin sensitivity, and adaptive responses to metabolic stress.
Mechanism of Action
Research indicates that MOTS-C can translocate from the mitochondria to the nucleus, where it modulates gene expression related to energy metabolism, mitochondrial biogenesis, and cellular stress defense. Through these pathways, it supports improved energy balance and metabolic flexibility under challenging physiological conditions.
Research Highlights
Supports healthy glucose metabolism
Enhances insulin sensitivity and energy regulation
Promotes mitochondrial health and cellular resilience
May aid in reducing fat accumulation and improving exercise performance
Studied for potential benefits in metabolic and age-related disorders, including obesity, insulin resistance, and osteoporosis
Molecular Information
Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Molecular Formula: C89H139N25O26S
Molecular Weight: ~2179.3 g/mol
Purity: ≥99%
Storage Instructions
Store lyophilized peptide at –20°C or below.
After reconstitution, refrigerate between 2–8°C.
Avoid repeated freeze-thaw cycles.
Disclaimer
All Pepgenix Peptides products are intended for laboratory research use only.
Not for human consumption, therapeutic use, or veterinary applications.
